Chronic Kidney Dysfunction Prevalence after Liver Transplantation in a Service in Espírito Santo
Keywords:
Liver transplant, Chronic renal failure, Organ transplantationAbstract
Introduction: The prevalence of chronic kidney disease (CKD) in post-liver transplant patients is high and widely variable, 35% to 77%, depending on the definition and methodology used in the studies. Despite the increase in the number of transplants performed worldwide, literature data on long-term post-transplant outcomes and complications remain scarce, especially in Brazil. Objectives: To evaluate a regional cohort after a minimum post-transplant follow-up of 2 years to verify the prevalence of CKD. Method: Retrospective, singlecenter, longitudinal descriptive study of the occurrences of CKD after liver transplantation. Patients were evaluated at the consultation immediately before the transplant (time 0) and at the consultation 2 years later (time 2). Results: Of the 163 records analyzed, it appears that the classification of CKD at time 0 and time 2 was, respectively, stage 1: 55.56% and 32.10%; stage 2: 34.72% and 46.91%; stage 3: 8.33% and 16.05%; stage 4: 1.39% and 2.47%; and stage 5: 0% and 2.47%. There was a significant association between creatinine at time 0 and time 2, with the cutoff point of 1.5 mg/dL. Regarding CKD, within 24 months, 20.99% of the sample had CKD itself. Conclusion: Creatinine increased from time 0 to time 2, with a cutoff point of 1.5 mg/dL, a significant value in the context of the patient’s prognosis. There was a worsening of renal function and categorization of patients 2 years after transplantation into more severe categories of chronic renal dysfunction when compared to time 0. Prevention and early identification of renal dysfunction in transplant recipients have an impact on patient and graft survival, becoming an important measure to be taken in the follow-up of these patients.
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Copyright (c) 2025 Mariana Poltronieri Pacheco, Ana Carolina Main Lucas, Letícia Scopel Miossi, Lara Pin Venturini, Livia Zardo Trindade
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