The Immune Response as a Model of (Really?) Random Natural Selection
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The natural selection analogy for the immune response is sophisticated. While the maturation of B lymphocytes resembles “survival of the fittest,” the formation of memory T lymphocytes prioritizes clonal diversity, which is crucial for fighting mutant pathogens. By reducing the TCR signal and the antigen affinity, the development of these memory cells can be accelerated. Thus, the immune strategy for long-term protection is diversity.
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1. Neumann J. The immune response as a model of random natural selection, from Charles Darwin to Susumo Tonegawa: a (provocative) text for non-immunologists. Braz J Transplant, 2025; 28(1): e2325. https://doi.org/10.53855/bjt.v28i1.684_ENG
2. Solouki S, Huang W, Elmore J, Limper C, Huang F, August A. TCR signal strength and antigen affinity regulate CD8+ memory T cells. J Immunol, 2020; 205(5):1217-27. https://doi.org/10.4049/jimmunol.1901167
3. Kavazović I, Han H, Balzaretti G, Slinger E, Lemmermann NAW, ten Brinke A, et al. Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity. PLoS Biol, 2020; 18(3): e3000648. https://doi.org/10.1371/journal.pbio.3000648
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Derechos de autor 2025 Amanda de Menezes Mayer, José Artur Bogo Chies
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
