Long-Term Impact In Hepatitis C Virus Infection In Post transplantation

Abstract

Purpose: The authors assessed the impact on the kidney transplantation associated to the C virus chronic hepatitis (HCV) infection, analyzing the complications, patients’ and graft survival. Methods: Retrospective study of 40 kidney transplant recipients bearers of HCV infection and 40 kidney transplant recipients no-bearers of HCV infection along the same post transplantation period. Results: The mean post transplantation time was 12.3 ± 4.5 years of patients bearers of HCV infection, and 12.5 ± 2.9 years of patients no-bearers of HCV infection (P=0.49). There was no statistical difference as to the age and gender of recipients or donors. The present renal function in patients bearers of HCV infection was 47.3 ± 24.9 ml/min, and 54.9 ± 27.2 ml/min in the group of no bearers (p= 0.48). The incidence of the graft and patient survival was similar in both groups. The main cause of death in both groups was bacterial infection (10% in HCV patients and 12.5% in the group of no bearers, p=0.63).The most common complication between both groups was acute allograft rejection and bacterial infection, and the incidence of diabetes mellitus showed no statistical difference. Abnormal levels of liver enzymes and cirrhosis were only observed in patients bearers of HCV infection. Conclusion: HCV infection did not show to have impact on the patient and graft survival and on complications in the post transplantation.