Síndrome de Guillain-Barré Secundária à Infecção por Citomegalovírus em Paciente Pediátrico Transplantado Renal

Daniela Saraiva Guerra Lopes; Iracy de Oliveira Araujo; Rodrigo Melo Gallindo; Cassio Tâmara Ribeiro; Paula Andréa dos Santos Genesio

Autores

Daniela Saraiva Guerra Lopes Instituto de Medicina Integral Prof. Fernando Figueira – Recife (PE) – Brasil. https://orcid.org/0009-0005-0640-0616
Iracy de Oliveira Araujo Instituto de Medicina Integral Prof. Fernando Figueira – Recife (PE) – Brasil. https://orcid.org/0009-0007-5920-8366
Rodrigo Melo Gallindo Instituto de Medicina Integral Prof. Fernando Figueira – Recife (PE) – Brasil. https://orcid.org/0000-0002-7801-175X
Cassio Tâmara Ribeiro Instituto de Medicina Integral Prof. Fernando Figueira – Recife (PE) – Brasil. https://orcid.org/0009-0002-5317-4939
Paula Andréa dos Santos Genesio Instituto de Medicina Integral Prof. Fernando Figueira – Recife (PE) – Brasil. https://orcid.org/0009-0002-5317-4939

Palavras-chave:

Transplante Renal, Criança, Síndrome de Guillain-Barré, Citomegalovírus

Resumo

A associação entre síndrome de Guillain-Barré (SGB) e citomegalovírus (CMV) já é bem estabelecida na literatura, tendo sido primeiramente relatada em 1967. Porém, essa associação é rara em pacientes transplantados de órgãos sólidos, apesar da incidência de infecção sintomática por CMV ser maior nesta população. Devido ao seu potencial de gravidade, alta morbidade e mortalidade, a possibilidade de SGB não pode ser afastada em caso de complicação neurológica em pacientes transplantados. Neste relato, é descrito um caso de SGB secundária a CMV em um paciente transplantado renal de 8 anos de idade, na faixa etária pediátrica, intervalo com ainda maior escassez de relatos sobre essa associação. O paciente apresentava sorologia (IgG e IgM) negativa para CMV em exames pré-transplante, enquanto o doador possuía IgG positiva, havendo dessa forma alto risco de desenvolvimento da doença. A abertura do quadro clínico ocorreu cerca de dois meses após a realização do transplante, com sintomas e evolução clássicos de SGB. São discutidos os aspectos clínicos, diagnósticos, de tratamento e de evolução da doença, além da relação com as evidências presentes na literatura mundial.

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