Impact of Physical Rehabilitation on Sexual Function of Patients after Liver Transplantation in a Teaching Hospital

Authors

Keywords:

Liver Transplantation, Physical Rehabilitation, Sexuality

Abstract

Objectives:  There is a lack of data regarding the effects of exercise on sexual function after liver transplantation (LT). This research, conducted in the Northeast of Brazil, aimed to assess the impact of an 8-week rehabilitation program on the sexual function of patients following LT, compared to a control group (CG) not participating in an exercise program. Methods:  This controlled, nonrandomized pilot study enrolled patients in an 8-week, thrice-weekly, comprehensive, supervised rehabilitation program initiated 1 month after LT. A nonrandomized CG of patients was selected to match the physical rehabilitation group (PRG) based on specific demographic data and disease severity. Results:  Both groups were comparable in baseline measurements; before the intervention, the mean sexual scores for PRG vs. CG were 62.9 (95%CI 56.8-68.8) and 54.8 (95%CI 48.7-61.0), respectively, and the difference was not statistically significant. After the intervention, the mean sexual scores for PRG vs. CG increased to 82.8 (95%CI 78.9-86.8) and 70.5 (95%CI 66.1-74.9), respectively, and were statistically significant. The effect of PR over the 8 weeks significantly impacted sexual function, with higher sexual scores in week 8 following rehabilitation compared to week 1 (83.2 ± 5.8 and 95%CI [71.6-94.6] vs. 62.4 ± 4.1 and 95%CI [54.6-70.3]; p < 0.001) for both genders. Conclusion:  This work contributes to filling a gap in studies exploring the positive effects of physical exercise on sexual function among patients after LT. This provides a framework for implementing timely interventions related to specific behaviors.

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References

1. Nascimento SML, Fabris MEM, Barros JM, Ribeiro LM, Frizanco AB, Santiago ALP, et al. Liver Transplantation in Brazil between 2010 and 2021: 30-day survival. Braz J Transplant, 2023; 26(1). https://doi.org/10.53855/bjt.v26i1.541_ENG

2. Lee JY, Shin DW, Oh JW, Kim W, Joo SK, Jeon MJ, et al. Non-alcoholic fatty liver disease as a risk factor for female sexual dysfunction in premenopausal women. PLoS One, 2017; 12(8): e0182708. https://doi.org/10.1371/journal.pone.0182708

3. Yoo HJ, Lee B, Jung EA, Kim SG, Kim YS, Yoo JJ. Prevalence and risk factors of erectile dysfunction in patients with liver cirrhosis: a systematic review and meta-analysis. Hepatol Int, 2023; 17(2): 452-62. https://doi.org/10.1007/s12072-021-10270-y

4. Ferrarese A, Hurtado Díaz de León I, Tapper EB, Burra P. Sexual health and function in liver disease. Hepatol Commun, 2025; 9(4): e0691. https://doi.org/10.1097/HC9.0000000000000691

5. Burra P, Germani G, Masier A, De Martin E, Gambato M, Salonia A, et al. Sexual dysfunction in chronic liver disease: is liver transplantation an effective cure? Transplantation, 2010; 89(12): 1425-9. https://doi.org/10.1097/TP.0b013e3181e1f1f6

6. Parolin MB, Coelho JC, Urbanetz AA, Pampuch M. Contracepção e gravidez após transplante hepático – uma visão atual. Arq Gastroenterol, 2009; 46(2): 154-8. https://doi.org/10.1590/S0004-28032009000200015

7. Abdo CH. The male sexual quotient: a brief, self-administered questionnaire to assess male sexual satisfaction. J Sex Med, 2007; 4(2): 382-9. https://doi.org/10.1111/j.1743-6109.2006.00414.x

8. Abdo CHN. Development and validation of female sexual quotient - a questionnaire to assess female. Rev Bras Med 2006 [cited 2006 Sept]; 63(9). Available at: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-945578

9. Moya-Nájera D, Moya-Herraiz Á, Compte-Torrero L, Hervás D, Borreani S, Calatayud J, et al. Combined resistance and endurance training at a moderate-to-high intensity improves physical condition and quality of life in liver transplant patients. Liver Transpl, 2017; 23(10): 1273-81. https://doi.org/10.1002/lt.24827

10. De Melo MB, Daldegan-Bueno D, Menezes Oliveira MG, de Souza AL. Beyond ANOVA and MANOVA for repeated measures: advantages of generalized estimated equations and generalized linear mixed models and its use in neuroscience research. Eur J Neurosci, 2022; 56(12): 6089-98. https://doi.org/10.1111/ejn.15858

11. Coelho JCU, Freitas ACD, Matias JEF, Pissaia Jr. A, Godoy JL. Sexual dysfunction in males with end-stage liver disease: partial recovery after liver transplantation. J Liver Dis Transplant, 2014:3:2 https://doi.org/10.4172/2325-9612.1000122

12. Park ES, Villanueva CA, Viers BR, Siref AB, Feloney MP. Assessment of sexual dysfunction and sexually related personal distress in patients who have undergone orthotopic liver transplantation for end-stage liver disease. J Sex Med, 2011; 8(8): 2292-8. https://doi.org/10.1111/j.1743-6109.2011.02264.x

13. Klein J, Tran SN, Mentha-Dugerdil A, Giostra E, Majno P, Morard I, et al. Assessment of sexual function and conjugal satisfaction prior to and after liver transplantation. Ann Transplant, 2013; 18: 136-45. https://doi.org/10.12659/AOT.883860

14. Karabulut, N., Koraş, K., & Gürçayır, D. Effects of liver transplantation on sexual function and quality of life. Psychol Health Med, 2021; 27(7): 1532-43. https://doi.org/10.1080/13548506.2021.1898003

15. Almuqahwi A, Alabdrabulridha H, Aljumaiah RM, Alfaifi AJ, Alnaim MF, Alfaifi IA, et al. A systematic review on the relationship between physical activity and sexual function in adults. Cureus, 2023; 15(12): e51307. https://doi.org/10.7759/cureus.51307

16. Obuekwe O, Clark H, Saffati G, Yatsenko T, Oscar-Thompson L, Riveros C, et al. The impact of solid organ transplantation on sexual dysfunction and infertility in older men and women: a claims based study. Int J Impot Res, 2025. https://doi.org/10.1038/s41443-025-01127-1

17. Norman R, King MT, Clarke D, Viney R, Cronin P, Street D. Does mode of administration matter. Comparison of online and face-to-face administration of a time trade-off task. Qual Life Res, 2010; 19(4): 499-508. https://doi.org/10.1007/s11136-010-9609-5

Published

2026-06-05

How to Cite

1.
Bentes C, Holanda MA, Tomaz BS, Mont’Alverne DGB, Cavalcante AG de M, Daher EDF, et al. Impact of Physical Rehabilitation on Sexual Function of Patients after Liver Transplantation in a Teaching Hospital. bjt [Internet]. 2026 Jun. 5 [cited 2026 Jul. 27];29. Available from: https://bjt.emnuvens.com.br/revista/article/view/778

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Original Paper