Thyroid Metastases from Hepatocellular Carcinoma after Liver Transplantation

Danilo Dias Avancini  Viana; Angel Evangelista Barroso   Magalhães; Dayane Laura da  Silva; Larissa Peixoto Teixeira; Larissa Ponte Dias; Clebia  Azevedo de Lima; Elodie Bomfim Hyppolito; Paulo Everton Garcia Costa; Gustavo Rêgo Coelho; José Huygens Parente Garcia

Authors

Danilo Dias Avancini Viana Universidade Federal do Ceará – Faculdade de Medicina – Fortaleza (CE) – Brazil. https://orcid.org/0009-0004-1740-915X
Angel Evangelista Barroso Magalhães Universidade Federal do Ceará – Departamento de Enfermagem – Fortaleza, (CE) – Brazil. https://orcid.org/0009-0007-8556-791X
Dayane Universidade Estácio – Escola de Enfermagem – Fortaleza, (CE) – Brazil. https://orcid.org/0009-0006-8790-5372
Larissa Peixoto Teixeira Universidade de Fortaleza – Faculdade de Medicina – Fortaleza (CE) – Brazil. https://orcid.org/0009-0007-3645-8039
Larissa Ponte Dias Universidade de Fortaleza – Faculdade de Medicina – Fortaleza (CE) – Brazil. https://orcid.org/0009-0007-8347-4365
Clebia Azevedo de Lima Universidade Federal do Ceará – Transplante Hepático – Fortaleza (CE) – Brazil. https://orcid.org/0000-0002-7762-7149
Elodie Bomfim Hyppolito Universidade Federal do Ceará – Transplante Hepático – Fortaleza (CE) – Brazil. https://orcid.org/0000-0002-6622-6585
Paulo Everton Garcia Costa Universidade Federal do Ceará – Transplante Hepático – Fortaleza (CE) – Brazil | Hospital São Carlos – Transplante Hepático – Fortaleza (CE) – Brazil. https://orcid.org/0000-0001-6589-1957
Gustavo Rêgo Coelho Universidade Federal do Ceará – Transplante Hepático – Fortaleza (CE) – Brazil | Hospital São Carlos – Transplante Hepático – Fortaleza (CE) – Brazil. https://orcid.org/0000-0003-0845-2864
José Huygens Parente Garcia Universidade Federal do Ceará – Transplante Hepático – Fortaleza (CE) – Brazil | Hospital São Carlos – Transplante Hepático – Fortaleza (CE) – Brazil. https://orcid.org/0000-0003-4401-137X

Keywords:

Hepatocellular Carcinoma, Neoplasm Metastasis, Thyroid Neoplasms

Abstract

Hepatocellular carcinoma (HCC) patients with metastases to the thyroid are extremely rare. A patient who underwent liver transplantation for HCC recurrence had metastatic thyroid recurrence detected 4 years later. A literature review identified six documented cases, analyzing relevant data on HCC with thyroid metastasis following liver transplantation. There is a prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) as etiologies of liver disease (83.3%), with alpha-fetoprotein (AFP) levels elevated in five cases. Additionally, the time between the diagnosis of HCC and thyroid metastasis was within 3 years. The patient remains clinically stable in outpatient follow-up, with an 8-month current survival after total thyroidectomy.

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References

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Thyroid Metastases from Hepatocellular Carcinoma after Liver Transplantation

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