Atezolizumab plus Bevacizumab as a Bridge for Liver Transplant in Hepatocellular Carcinoma

Authors

  • Gabriela Azevedo Solino Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória – Departamento de Medicina – Vitória/ES – Brasil.
  • Raphael Paiva Cock Ferreira Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória – Departamento de Medicina – Vitória/ES – Brasil.
  • Luiz Augusto Carneiro D’Albuquerque Universidade de São Paulo – Departamento de Transplante Hepático – São Paulo/SP – Brasil.
  • Alberto Queiroz Farias Universidade de São Paulo – Departamento de Transplante Hepático – São Paulo/SP – Brasil.
  • Lívia Zardo Trindade Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória – Departamento de Gastroenterologia e Hepatologia – Vitória/ES – Brasil.
  • Vitor Fiorin de Vasconcelos Universidade Federal do Espírito Santo – Departamento de Oncologia – Vitória/ES – Brasil.
  • Mariana Poltronieri Pacheco Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória – Departamento de Gastroenterologia e Hepatologia – Vitória/ES – Brasil.

Keywords:

Carcinoma, Hepatocellular, Liver Transplantation, Immunotherapy

Abstract

We report the case of a 68-year-old male with alcohol-related cirrhosis, diagnosed with hepatocellular carcinoma (HCC) noteligible for liver transplant. After immunotherapy with atezolizumab associated with bevacizumab, he underwent a successful living donor liver transplantation (LT), not showing disease evidence or graft injury, maintaining clinically and radiologically stable 14 months after surgery. This is a successful report of combined atezolizumab plus bevacizumab being used as a bridge to LT in a patient with HCC, showing an important finding in therapy in patients with unresectable tumors at diagnosis.

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Published

2023-02-11

How to Cite

Solino, G. A. ., Ferreira, R. P. C. ., D’Albuquerque, L. A. C. ., Farias, A. Q. ., Trindade, L. Z., Vasconcelos, V. F. de ., & Pacheco, M. P. . (2023). Atezolizumab plus Bevacizumab as a Bridge for Liver Transplant in Hepatocellular Carcinoma. Brazilian Journal of Transplantation, 26. Retrieved from https://bjt.emnuvens.com.br/revista/article/view/444

Issue

Vol. 26 (2023)

Section

Case Report

License

Copyright (c) 2023 Gabriela Azevedo Solino; Raphael Paiva Cock Paiva Cock Ferreira; Luiz Augusto Carneiro D’Albuquerque, Alberto Queiroz Farias, Lívia Zardo Trindade, Vitor Fiorin de Vasconcelos, Mariana Poltronieri Pacheco

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.