Therapy in cyclosporine-induced gingival overgrowth in renal transplant patients

Abstract

Cyclosporine A-induced gingival overgrowth in kidney transplant patients usually appears one to three months after the initial therapy. The severity of the gingival overgrowth varies from mild changes of the gingival margin up to the totally covered dental crown, causing esthetic and functional problems. The purpose of this paper is to relate two clinical cases of gingival enlargement and the respective therapy. In the first case, the periodontal health was maintained with professional biofilm control. The second case was treated for surgical excision, followed by a periodontal support therapy. The clinical aspect of the CG in both cases improved, since therapies reduced the inflammation. The surgical therapy associated to biofilm control was able to eliminate fibrosis, improving the periodontitis condition. Concluding, our findings suggest that the gingival overgrowth was reduced after biofilm dental control or after combining it with gingivectomy/gingivoplasty.