Cicatricial behavior and response to intraoperatory mechanical ventilation of the transplanted segment of the trachea (autologous and homologous transplant of the entire segment) in rabbits

Abstract

Purpose: to study the cicatricial behavior and response to the intraoperative mechanical ventilation of the transplanted segment of the trachea in rabbits. Method: two groups were assessed: autologous (group I) and homologous transplant (group II) of the entire segment of the trachea in rabbits. Result: The Qui-square test showed no significant statistical difference between the studied groups. Regarding the time of survival, the Qui-square test (p<0.05) revealed that averages were considered statistically different (tc = - 3.60), and the survival of Group I was longer than Group II. The direct necroscopy and radiological assessment using the Kruskal-Wallis test (p<0.05) showed no statistical difference between groups. Complications such as stenosis, formation of granulomas and fistulas were observed in both groups. Regarding the intraoperative behavior and response to the mechanical ventilation, the Kruskal-Wallis test (p<0.05) showed no significant statistical difference between Groups I and II. Both groups showed good resistance to the high pressure of the intraoperative mechanical ventilation. By using the Kruskal-Wallis test, no significant statistical difference was observed between groups concerning the anatomicopathological results. Group I had a higher prevalence of granuloma, bone metaplasia, necrosis in the region of the anastomosis, fibroplasia, graft reepithelialization, and polymorphonuclear infiltration. Conclusion: the reepitheliazation and early and late inflammatory reactions were observed in both groups, but animals with autologous transplant had a better clinical evolution and survival for a longer time than those which received homologous transplant.