Serologic potential in solid organ donors in Santa Catarina from 2001 to 2007

Abstract

Purpose: This study assessed the profile of serological markers of blood-borne diseases among potential donor of solid organs. Methods: We conducted an epidemiological survey based on secondary data. The population studied comprised 1424 potential donors of solid organs in the Santa Catarina State from January 2001 to December 2007. Serological analysis was conducted by the Center for Hematology and Hemothera- py in the Santa Catarina State (HEMOSC). Demographic data were collected by the Center of Organs donation in the state (CNCDO/SC). The variables analyzed include serological test results in potential donors of solid organs, as well as their sex, age and year of examination. Results: Among 1424 subjects examined, 551 (38.7%) were females and 873 (61.3%) males. Seroprevalence of disease markers was as follows: 21.7% with anti-HBc, 3,9% with HBsAg, 1,3% with anti-HCV, 0,3% with Chagas disease, 0,9% with VDRL marker for syphilis, 0,3% with HTLV 1 or 2, 0,5% with HIV 1 or 2, 38.2% with toxoplasmosis IgG, 2,3% with toxoplasmosis IgM, 46,2% with CMV IgG and 2,6% with CMV IgM. The seroprevalence of CMV IgM was higher in women (p <0.01). The other markers showed no statistically significant difference between genders. Conclusions: There was a higher percentage of males among potential donors for donation of organs. During the period analyzed, an increase in the percentage of potential donor above 60 years old and HBsAg-positive men was observed. The seroprevalence of HCV, HIV, HTLV and Chagas disease was low with no change along the period studied. Infection by cytomegalovirus and toxoplasmosis were high, and acute infection uncommon. Cytomegalovirus was more frequent in women and younger individuals.