COVID-19 in renal-transplanted recipients: a narrative review

Authors

  • Suellen Rodrigues Martins Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Lorraine Vieira Alves Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Marta Lamounier Moura Vargas Corgozinho Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Jenner Karlisson Pimenta dos Reis Universidade Federal de Minas Gerais - Faculdade de Medicina Veterinária - Belo Horizonte/MG - Brasil.
  • Bruno Eduardo Fernandes Mota Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Kátia de Paula Farah Universidade Federal de Minas Gerais - Faculdade de Medicina - Belo Horizonte/MG - Brasil.
  • Karina Braga Gomes Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Luci Maria Santana Dusse Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Patrícia Nessralla Alpoim Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.
  • Ana Paula Lucas Mota Universidade Federal de Minas Gerais - Faculdade de Farmácia - Belo Horizonte/MG - Brasil.

DOI:

https://doi.org/10.53855/bjt.v24i2.19

Keywords:

Communicable Disease, Coronavirus Infections, Renal Insufficiency, Kidney Transplantation

Abstract

COVID-19 is an emerging disease mainly associated with Severe Acute Respiratory Syndrome (SARS). This disease causes a cytokine storm release in response to viral infection, and can lead to several systemic complications. Acute kidney injury (AKI) is one of these complications and renal replacement therapy may be necessary for the infected patient. In this context, renal-transplanted recipients (RTR) and patients with chronic kidney diseases are in the risk groups for COVID-19 due to their increased inflammatory state and endothelial dysfunction. Furthermore, maintenance immunosuppressive therapy in RTR can also be another complicating factor, since it influences the response from the immune system against pathogens, including SARS-CoV-2. However, it is believed that the worst outcomes of COVID-19 are mainly caused by an exaggerated inflammatory response than to the direct virus action; therefore, in a hyper-inflammatory state, immunosuppression therapy could be beneficial. This narrative review aims to present the main clinical and laboratory findings of 22 studies involving RTR affected by COVID-19. This review can contribute to the management of COVID-19 and its consequences in this risk group.

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Published

2021-09-07

How to Cite

Martins, S. R., Alves, L. V., Corgozinho, M. L. M. V., Reis, J. K. P. dos, Mota, B. E. F., Farah, K. de P., Gomes, K. B., Dusse, L. M. S., Alpoim, P. N., & Mota, A. P. L. (2021). COVID-19 in renal-transplanted recipients: a narrative review. Brazilian Journal of Transplantation, 24(2), 51–71. https://doi.org/10.53855/bjt.v24i2.19

Issue

Section

Review Article