Pharmacological pre-conditioning during organ extraction surgery can improve the graft feasibility?

Abstract

Brazil has the biggest public service of transplantation in the world; however, the quality of organ attained is uncertain, especially due to deficiencies in providing care to the brain-dead organ donor with impact on the graft’s function. The brain-dead process causes hemo- dynamic changes, endocrine-metabolic syndrome, ischemia-reperfusion injury and inflammatory response that also have impact on the transplanted graft’s function. Volatile halogenated anesthetics (isoflurane, sevoflurane) have other than anesthetic properties resulting in endogenous adaptive response to ischemic injuries. It is suggested to administrate halogenated anesthetics to brain-dead organ donor in the organ extraction surgery probably resulting in improvement to the post-transplantation organ function and decrease in the acute rejection.