Diferenças de Gênero na COVID-19 entre Receptores de Transplante de Fígado: Resultados de uma Coorte Multicêntrica Brasileira
Palavras-chave:
Transplante Hepático, COVID-19, Necessidades Específicas de GêneroResumo
Introdução: A literatura existente apresenta perspectivas variadas sobre o impacto da COVID-19 em receptores de transplante de fígado. No entanto, nenhuma pesquisa investigou especificamente o papel das diferenças de gênero na manifestação da COVID-19 entre os receptores de transplante de fígado. Este estudo pretende examinar os efeitos da COVID-19 em receptores de transplante de fígado, com foco nas diferenças de gênero na apresentação e progressão da doença. Métodos: Conduzida como um estudo de coorte histórico multicêntrico, esta pesquisa coletou registros de pacientes por meio de um questionário on-line. O principal objetivo foi avaliar a mortalidade relacionada à COVID. Além disso, foram coletados dados demográficos, clínicos e laboratoriais relativos à apresentação e progressão da doença. Resultados: O estudo incluiu um total de 283 pacientes, sendo 76 do sexo feminino e 206 do sexo masculino. O período médio de acompanhamento para os homens foi de 99 dias (IQR 38-283), enquanto para as mulheres foi de 126 dias (IQR 44-291). Foi observada uma maior prevalência de doença cardiovascular nos homens (p=0,002). As mulheres frequentemente apresentavam perda de olfato (p=0,021), enquanto os homens geralmente apresentavam febre (p=0,031). Os níveis de ALT e gama-glutamil transferase foram significativamente elevados nos homens (p=0,008 e 0,004, respectivamente). Embora tenha havido uma tendência de aumento da mortalidade nos homens, ela não alcançou significância estatística. Conclusão: Este estudo é a primeira tentativa de investigar as diferenças de gênero na COVID-19 entre os receptores de transplante de fígado. Nossos achados destacam a necessidade de uma abordagem abrangente e personalizada para tratar essa população de pacientes e ressaltam a importância de elucidar melhor a apresentação da doença nesses indivíduos.
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Copyright (c) 2023 Elaine Cristina Ataide, Eduardo Riccetto, Tercio Genzini, Regina Gomes Santos, Lucio F Pacheco Moreira, Laura Cristina Machado Pinto, Raquel S B Stucchi, Simone Reges Perales, Leticia Zanaga, Renato Ferreira da Silva, Rita C M Ferreira da Silva, Luciana Haddad, Luiz A C D´'Albuquerque, Marcio Dias de Almeida, Andre Watanabe, Gustavo S Peixoto, Claudio Moura Lacerda de Melo, Renata Ferreira, Nertan Luiz Tefilli, Marcia Halpern, Maira Silva Godoy, Marcelo Nogara, Jorge Marcelo Padilla Mancero, Huda Maria Noujaim, José Huygens Parente Garcia, Erika Bevilaqua Rangel, Ilka de Fátima Santana Ferreira Boin
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
