Transplante Hepático em Pacientes com Metástases Hepáticas Colorretais: Revisão da Literatura
Palavras-chave:
Transplante de Fígado, Metástase, Câncer ColorretalResumo
O câncer colorretal (CCR) encontra-se em crescimento e já é o segundo em incidência, tanto em homens quanto em mulheres. Cerca de 50% dos pacientes com CCR desenvolvem metástases hepáticas (MH), e em cerca de 35% desses as lesões permanecem restritas ao fígado. Infelizmente, apenas 20 a 40% dos pacientes com MHCCR apresentam doença ressecável, ficando os demais com prognóstico sombrio, com sobrevida em 5 anos de cerca de 10%, apesar de tratamentos avançados multimodais, sistêmicos e locorregionais. Desde a década de 1980, transplantes de fígado (TF) foram realizados para tratamento de pacientes com MHCCR irressecáveis. Sobrevidas pobres pouco superiores à quimioterapia sistêmica foram observadas na época. Com as publicações do grupo de Oslo a partir de 2013 e o estabelecimento de critérios de seleção e estratégias de imunossupressão, alcançaram-se sobrevidas satisfatórias que impulsionaram estudos multicêntricos que estão confirmando os achados noruegueses e consolidando o TF como alternativa de tratamento para pacientes selecionados com MHCCR irressecáveis. Este estudo faz uma revisão sistemática dos artigos publicados envolvendo o tema TF em MHCCR, incluindo relatos de caso, séries de casos, estudos multicêntricos e revisões sobre o tema, com o objetivo de mostrar o desenvolvimento, os casos iniciais em diversos centros e o estado atual dessa importante alternativa de tratamento.
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Copyright (c) 2026 Tércio Genzini, Keli Camila Vidal Grochoski , Fernando Kruglensky Lerner , Marcella Costa Genzini, Beatriz Thomé Barbosa, Vanessa Pizzino de Luca , Marcella Adorno Chiavegatto, Aloysio Ikaro Martins Coelho Costa , Marcelo Perosa
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
