Particularidades no Manejo do Trato Urinário antes do Transplante Renal Pediátrico em Crianças Pequenas
Palavras-chave:
Transplante de Rim, Lactentes, Baixo Peso, Doença UrológicaResumo
O número de transplantes renais em crianças pequenas (bebês ou com menos de 15 kg) aumentou devido à melhoria do diagnóstico pré-natal, ao encaminhamento mais precoce para centros especializados e aos avanços no tratamento de pacientes com insuficiência renal. A maioria desses pacientes tem anomalias congênitas do rim e do trato urinário, que precisam ser corrigidas antes do transplante. Para enfrentar esse desafio, a presença de um urologista pediátrico trabalhando em conjunto com uma equipe multidisciplinar experiente é fundamental. Este estudo fornece uma revisão narrativa compilando detalhes sobre o manejo urológico do trato urinário de pacientes de baixo peso com doença renal crônica e anomalias congênitas do rim e do trato urinário (CAKUT) encaminhados para transplante renal (TR). Objetivos: Realizar uma revisão narrativa sobre a correção urológica em crianças pequenas antes do TR. Métodos: Foram revisados artigos publicados em língua inglesa nos últimos 20 anos. As palavras-chave consideradas para a pesquisa e seleção de artigos foram TR pediátrico ou transplante de rins e crianças, ou crianças pequenas, ou lactentes pequenos, ou crianças jovens, ou lactentes jovens e reconstrução do trato urinário e CAKUT. Alguns artigos referenciados para elucidar os aspectos urológicos da revisão também foram incluídos.
Downloads
Referências
Salvatierra O, Millan M, Concepcion W. Pediatric renal transplantation with considerations for successful outcomes. Semin Pediatr Surg. 2006;15(3):208-17. https://doi.org/10.1053/j.sempedsurg.2006.03.007
Lemoine CP, Pozo ME, Riccardo S. Overview of pediatric kidney transplantation. Semin Pediatr Surg. 2022;31(3):151194. https://doi.org/10.1016/j.sempedsurg.2022.151194
Feltran LS, Cunha MFM, Perentel SMRM, Hamamoto F, Camargo MFC, Komi S, et al. Is preoperative preparation time a barrier to small children being ready for kidney transplantation? Transplantation. 2020;104(3):591-6. https://doi.org/10.1097/TP.0000000000002807
Alam S, Sheldon C. Urological issues in pediatric renal transplantation. Curr Opin Urol. 2008;18(4):413-8. https://doi.org/10.1097/MOU.0b013e328302ede7
McEnery PT, Stablein DM, Arbus G, Tejani A. Renal transplantation in children – A report of the North American Pediatric Renal Transplant Cooperative Study. N Engl J Med. 1992;326(26):1727-32. https://doi.org/10.1056/NEJM199206253262602
Feltran LS, Genzani CP, Fonseca MJBM, da Silva EF, Baptista JC, de Carvalho MFC, et al. Strategy to enable and accelerate kidney transplant in small children and results of the first 130 transplants in children ≤ 15 kg in a single center. Transplantation. 2020;104(8):e236-42. https://doi.org/10.1097/TP.0000000000003300
Gander R, Asensio M, Royo GF, Molino JA, Ariceta G, Lara LE, et al. Kidney transplantation in children weighing 15 kg or less is challenging but associated with good outcome. J Pediatr Urol. 2017;13(3):279.E1-7. https://doi.org/10.1016/j.jpurol.2017.02.025
Ewalt DH, Allen TD. Urinary tract reconstruction in children undergoing renal transplantation. Adv Ren Replace Ther.1996;3(1):69-76. https://doi.org/10.1016/s1073-4449(96)80042-2
Weitz M, Laube GF, Schmidt M, Krupka K, Murer L, Müller D, et al. Outcome of renal transplantation in small infants: a match-controlled analysis. Pediatr Nephrol. 2018;33(6):1057-68. https://doi.org/10.1007/s00467-018-3895-5
Gomes AL, Koch-Nogueira PC, de Camargo MF, Feltran Lde S, Baptista-Silva JC. Vascular anastomosis for paediatric renal transplantation and new strategy in low-weight children. Pediatr Transplant. 2014;18(4):342-9. https://doi.org/10.1111/petr.12248
Theodorou C, Katsifotis C, Bocos J, Moutzouris G, Stournaras P, Kostakis A. Urodynamics prior to renal transplantation – Its impact on treatment decision and final results. Scand J Urol Nephrol. 2003;37(4):335-8. https://doi.org/10.1080/00365590310001674
Sackett DD, Singh P, Lallas CD. Urological involvement in renal transplantation. Int J Urol. 2011;18(3):185-93. https://doi.org/10.1111/j.1442-2042.2010.02707.x
McKay AM, Kim S, Kennedy SE. Long-term outcome of kidney transplantation in patients with congenital anomalies of the kidney and urinary tract. Pediatr Nephrol. 2019;34(11):2409-15. https://doi.org/10.1007/s00467-019-04300-z
Bauer SB, Nijman RJ, Drzewiecki BA, Sillen U, Hoebeke P, International Children’s Continence Society Standardization Subcommittee. International Children’s Continence Society standardization report on urodynamic studies of the lower urinary tract in children. Neurourol Urodyn. 2015;34(7):640-7. https://doi.org/10.1002/nau.22783
Farrugia MK, Malone PS. Educational article: the Mitrofanoff procedure. J Pediatr Urol. 2010;6(4):330-7. https://doi.org/10.1016/j.jpurol.2010.01.015
Fernandez HE, Foster BJ. Long-term care of the pediatric kidney transplant recipient. Clin J Am Soc Nephrol. 2022;17(2):296-304. https://doi.org/10.2215/CJN.16891020
Hebert SA, Swinford RD, Hall DR, Au JK, Bynon JS. Special considerations in pediatric kidney transplantation. Adv Chronic Kidney Dis. 2017;24(6):398-404. https://doi.org/10.1053/j.ackd.2017.09.009
Donckerwolcke RA, Bunchman TE. Hemodialysis in infants and small children. Pediatr Nephrol. 1994;8(1):103-6. https://doi.org/10.1007/BF00868283
Cornwell LB, Ingulli EG, Mason MD, Ewing E, Riddell JV. Renal transplants due to congenital anomalies of the kidney and urinary tract (CAKUT) have better graft survival than non-CAKUT controls: analysis of over 10,000 patients. Urology. 2021;154:255-62. https://doi.org/10.1016/j.urology.2021.01.005
Larkins NG, Wong G, Alexander SI, McDonald S, Prestidge C, Francis A, et al. Survival and transplant outcomes among young children requiring kidney replacement therapy. Pediatr Nephrol. 2021;36(8):2443-52. https://doi.org/10.1007/s00467-021-04945-9
Passoni NM, Peters CA. Managing ureteropelvic junction obstruction in the young infant. Front Pediatr. 2020;8:242. https://doi.org/10.3389/fped.2020.00242
EAU Guidelines. Edn. presented at the EAU Annual Congress Milan 2023. ISBN 978-94-92671-19-6
Nazer II, Alhashmi G, Sharief SN, Hefni NA, Ibrahim A, El-Desoky SM, et al. A case of urinary bladder agenesis and bilateral ectopic ureters: a case report. BMC Urol. 2018;18(1):83. https://doi.org/10.1186/s12894-018-0396-6
Viswanathan A, Leffler T, Paloian N, Cain M, McKenna PH. Early transplantation into a vesicostomy: a safe approach for managing patients with severe obstructive lesions who are not candidates for bladder augmentation. J Pediatr Urol. 2018;14(4):332.E1-6. https://doi.org/10.1016/j.jpurol.2018.07.022
Christman MS, Canning DA, Schast AP, Baluarte HJ, Kaplan BS. Renal transplantation into a diverted urinary system-is it safe in children? J Urol. 2013;190(2):678-82. https://doi.org/10.1016/j.juro.2013.02.019
Klaus R, Lange-Sperandio B. Chronic kidney disease in boys with posterior urethral valves – Pathogenesis, prognosis and management. Biomedicines. 2022;10:1894. https://doi.org/10.3390/ biomedicines10081894
Capizzi A, Zanon GF, Zacchello G, Rigamonti W. Kidney transplantation in children with reconstructed bladder. Transplantation. 2004;77(7):1113-6. https://doi.org/10.1097/01.tp.0000116710.73099.8a
Torricelli FCM, Watanabe A, Piovesan AC, David-Neto E, Nahas WC. Urologic issues in pediatric transplant recipients. Transl Androl Urol. 2019;8(2):134-40. https://doi.org/10.21037/tau.2018.06.17
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2024 Priscila Cardoso Braz Ascar, Jovelino Quintino de Souza Leão, Maria Fernanda Camargo de Carvalho, Paulo
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.